"SNU hospital cardiologists developed a way to transdifferentiate adult skin fibroblasts (SFBs) directly into vascular endothelial cells (iECs) without turning the fibroblasts into induced pluripotent stem cells. Up until now, researchers generally tried to cultivate induced pluripotent stem cells from the fibroblasts and then transdifferentiate the stem cells into vascular endothelial cells. However, this traditional process can cause an outbreak of tumors and cultivating stem cells can be very complicated, making the technology's commercialization difficult."